Sepsis is a life threatening condition that requires an early and precise diagnosis to improve survival rates. Many tests are required to confirm the diagnosis and current methods such as blood cultures are slow and often unreliable. This leads to delays in the treatment, worsening the condition that can lead to tissue damage, multi-organ failure and death. Electric field (E-field) lysis is a promising technique to enrich pathogens, keeping bacteria intact for further diagnostic tests. This has the potential to be used as a faster technique for the sepsis detection, but the samples have to be processed to lower the volume and be compatible with the current diagnostics techniques. This work explores the use of acoustic trapping, a non contact method that used sound waves to manipulate particles, to reduce the excess volume from the E-field lysis experiments, assessing their effectiveness trapping lysate and bacteria. The goal is to evaluate if this technique could potentially become an alternative to current methods.
Date of Award | 2024 |
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Original language | English |
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Supervisor | Jaroslaw Jacak (Supervisor) & Salomé Gutiérrez Ramos (Supervisor) |
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Acoustic forces as a potential toolfor the enrichment of biologicalsamples
Alvarado Gonzalez, A. (Author). 2024
Student thesis: Master's Thesis