TY - JOUR
T1 - Visualisierung lokaler kortikaler Defekte im Charcot-Fuß mittels Mikrocomputertomographie
AU - Senck, Sascha
AU - Plank, Bernhard
AU - Kastner, Johann
AU - Ramadani, Florin
AU - Trieb, Klemens
AU - Hofstaetter, Stefan G.
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2015/1
Y1 - 2015/1
N2 - Background: In the pathogenesis of diabetic neuropathic osteoarthropathy (Charcotʼs foot) fractures cause chronic destruction of soft tissue and bone structure. To improve an early diagnosis of Charcot foot, modern diagnostic imaging is mainly based on magnetic resonance imaging (MRI), for example in relation to the detection of cortical bone fractures. Objectives: In this study we investigated the cortical microstructure in cases of Charcot foot with respect to fractures and porosity in order to visualize local cortical defects. This may substantiate recent efforts in a reclassification based on MRI. Material and methods: Using microcomputed tomography (microCT) we investigated bone parameters, such as cortical thickness and porosity in order to quantify the local metatarsal microstructure in cases of Charcot foot. Results: All bone samples showed a high degree of cortical porosity including pores that perforated the cortical bone. The data suggest that areas with reduced cortical thickness coincide with large cortical pores that may serve as initial points for fractures. Whether the detected microfractures are physiological or artefacts of preparation could not be determined. Conclusion: By means of microCT we were able to visualize and quantify the extent of cortical porosity for the first time in high resolution. The data suggest that both cortical fractures and cortical porosity play an important role in the pathogenesis in cases of Charcot foot.
AB - Background: In the pathogenesis of diabetic neuropathic osteoarthropathy (Charcotʼs foot) fractures cause chronic destruction of soft tissue and bone structure. To improve an early diagnosis of Charcot foot, modern diagnostic imaging is mainly based on magnetic resonance imaging (MRI), for example in relation to the detection of cortical bone fractures. Objectives: In this study we investigated the cortical microstructure in cases of Charcot foot with respect to fractures and porosity in order to visualize local cortical defects. This may substantiate recent efforts in a reclassification based on MRI. Material and methods: Using microcomputed tomography (microCT) we investigated bone parameters, such as cortical thickness and porosity in order to quantify the local metatarsal microstructure in cases of Charcot foot. Results: All bone samples showed a high degree of cortical porosity including pores that perforated the cortical bone. The data suggest that areas with reduced cortical thickness coincide with large cortical pores that may serve as initial points for fractures. Whether the detected microfractures are physiological or artefacts of preparation could not be determined. Conclusion: By means of microCT we were able to visualize and quantify the extent of cortical porosity for the first time in high resolution. The data suggest that both cortical fractures and cortical porosity play an important role in the pathogenesis in cases of Charcot foot.
KW - Charcot-Fuss
KW - Mikro-Computertomographie
KW - Porosity, cortical
KW - Microstructure, cortical
KW - Osteoarthropathy, diabetic neuropathic
KW - Thickness, cortical
KW - New classification
KW - Tomography, X-Ray Computed/methods
KW - Humans
KW - Foot Bones/abnormalities
KW - Arthropathy, Neurogenic/diagnostic imaging
KW - Fractures, Bone/diagnostic imaging
KW - Radiographic Image Enhancement/methods
KW - Diabetic Foot/diagnostic imaging
KW - Charcot-Fuss
KW - Mikro-Computertomographie
UR - http://www.scopus.com/inward/record.url?scp=84925490428&partnerID=8YFLogxK
U2 - 10.1007/s00132-014-3053-0
DO - 10.1007/s00132-014-3053-0
M3 - Artikel
C2 - 25476840
SN - 0085-4530
VL - 44
SP - 8
EP - 13
JO - Orthopade
JF - Orthopade
IS - 1
ER -