Urinary eosinophil protein X in relation to disease activity in childhood asthma

E. Lugosi, G. Halmerbauer, T. Frischer, D. Y. Koller

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The clinical use of urinary eosinophil protein X (U-EPX) measurements in monitoring inflammation in childhood asthma was investigated. U-EPX and pulmonary function were assessed in 80 children with bronchial asthma and 24 healthy, age-matched controls. In addition, 14 patients with asthma were re- examined after 1-2 months. U-EPX levels were increased in children with asthma compared with controls (median 68.4 vs 35.3 μg/mmol creatinine; P<0.0001). In addition, U-EPX levels were higher in symptomatic than in asymptomatic patients (median 123.5 vs 48.9 μg/mmol creatinine; P<0.0001) independent of treatment modalities (i.e., inhaled steroids or disodium cromoglycate) or atopy (median 65.1 vs 86.0 μg/mmol creatinine). Furthermore, U-EPX levels were significantly correlated with pulmonary function. During the follow-up period, changes in U-EPX values were significantly related to changes in pulmonary function. In conclusion, our findings demonstrate that eosinophil activation can be measured in urine in childhood asthma. Concentrations of U-EPX are related to disease activity and pulmonary function, as shown in both cross-sectional and longitudinal analyses, but are independent of atopy and treatment modalities. Measurement of U-EPX may be useful in assessing the inflammatory process and therefore in the management of childhood asthma.

Original languageEnglish
Pages (from-to)584-588
Number of pages5
JournalAllergy
Volume52
Issue number5
DOIs
Publication statusPublished - 1997

Keywords

  • Asthma
  • Children
  • Eosinophil protein X (EPX)
  • Pulmonary function
  • Urine
  • Severity of Illness Index
  • Cross-Sectional Studies
  • Humans
  • Male
  • Ribonucleases
  • Maximal Expiratory Flow-Volume Curves
  • Blood Proteins/analysis
  • Asthma/diagnosis
  • Eosinophil-Derived Neurotoxin
  • Inflammation/diagnosis
  • Forced Expiratory Volume
  • Vital Capacity
  • Adolescent
  • Maximal Expiratory Flow Rate
  • Female
  • Residual Volume
  • Peak Expiratory Flow Rate
  • Child
  • Longitudinal Studies

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