Abstract
The edentulous ovine diastema represents a
suitable region for implantological research. Due
to distinctive embryonic origin and mechanical
loading, the edentulous diastema may respond
differently to osteoporosis than tooth-bearing
areas. To test this assumption, we subjected
geriatric sheep to ovariectomy, calcium-/vitamin-
D-restricted diet, and methylprednisolone
administration. Adult control sheep remained
untreated. Structural parameters and bone mineral
density were determined by microcomputed
tomography and conventional computed
tomography, respectively. We report that the
trabecular microstructure in the diastema was
preserved from catabolic changes. In contrast, the
premolar maxillary region of osteoporotic sheep
had diminished trabecular bone mineral density,
with the corresponding structural deteriorations.
These results suggest that maxillary trabecular
bone of the edentulous diastema does not respond
to catabolic changes which occur in the toothbearing
area in osteoporosis. Our findings
imply that regional anatomic domains must be
considered in the planning of pre-clinical studies,
taking osteoporotic changes into account.
Original language | English |
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Pages (from-to) | 866-870 |
Number of pages | 5 |
Journal | Journal of Dental Research |
Volume | 87 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2008 |
Keywords
- μCT
- Maxilla
- Osteoporosis
- Sheep
- Trabecular bone