Trabecular bone structures in the edentulous diastema of osteoporotic sheep

Gabriella Dvorak, Reinhard Gruber, Dietmar Salaberger, Gerald Zanoni

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The edentulous ovine diastema represents a suitable region for implantological research. Due to distinctive embryonic origin and mechanical loading, the edentulous diastema may respond differently to osteoporosis than tooth-bearing areas. To test this assumption, we subjected geriatric sheep to ovariectomy, calcium-/vitamin- D-restricted diet, and methylprednisolone administration. Adult control sheep remained untreated. Structural parameters and bone mineral density were determined by microcomputed tomography and conventional computed tomography, respectively. We report that the trabecular microstructure in the diastema was preserved from catabolic changes. In contrast, the premolar maxillary region of osteoporotic sheep had diminished trabecular bone mineral density, with the corresponding structural deteriorations. These results suggest that maxillary trabecular bone of the edentulous diastema does not respond to catabolic changes which occur in the toothbearing area in osteoporosis. Our findings imply that regional anatomic domains must be considered in the planning of pre-clinical studies, taking osteoporotic changes into account.
Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalJournal of Dental Research
Issue number9
Publication statusPublished - Sept 2008


  • μCT
  • Maxilla
  • Osteoporosis
  • Sheep
  • Trabecular bone


Dive into the research topics of 'Trabecular bone structures in the edentulous diastema of osteoporotic sheep'. Together they form a unique fingerprint.

Cite this