Single molecule reader for high-throughput bioanalysis

Jan Hesse, Jaroslaw Jacak, Alois Sonnleitner, Otmar Höglinger, Gerhard Schütz

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


We report here the development of a device for single-molecule imaging on large surface areas. A CCD camera operated in time delay and integration mode is synchronized with the movement of a sample scanning stage, enabling continuous data acquisition. Experiments on single fluorescent lipid molecules in supported lipid bilayers and on stained living cells demonstrate the capabilities of the method. Areas of up to 5 x 5 mm2 were recorded within 11 min at a pixel size of 129 nm.

Original languageEnglish
Pages (from-to)5960-5964
Number of pages5
JournalAnalytical Chemistry
Issue number19
Publication statusPublished - 1 Oct 2004


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