TY - GEN
T1 - Robust tube-based predictive control of blood glucose concentration in type 1 diabetes
AU - Kirchsteiger, Harald
AU - Del Re, Luigi
PY - 2013
Y1 - 2013
N2 - This paper investigates the applicability of tube-based robust MPC to control the blood glucose concentration in type 1 diabetic subjects through simulation studies. An existing, widely used nonlinear time-invariant metabolic simulation model is adopted and extended with several physiologically motivated uncertainties to account for the underlying intra-patient variability observed in real patients. Results on a virtual subject show that robustness to uncertainties can be improved and the risk of hypoglycemia reduced, without increasing the online computational demands compared to the conventional model predictive control approach.
AB - This paper investigates the applicability of tube-based robust MPC to control the blood glucose concentration in type 1 diabetic subjects through simulation studies. An existing, widely used nonlinear time-invariant metabolic simulation model is adopted and extended with several physiologically motivated uncertainties to account for the underlying intra-patient variability observed in real patients. Results on a virtual subject show that robustness to uncertainties can be improved and the risk of hypoglycemia reduced, without increasing the online computational demands compared to the conventional model predictive control approach.
UR - http://www.scopus.com/inward/record.url?scp=84902344251&partnerID=8YFLogxK
U2 - 10.1109/CDC.2013.6760189
DO - 10.1109/CDC.2013.6760189
M3 - Conference contribution
AN - SCOPUS:84902344251
SN - 9781467357173
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 2084
EP - 2089
BT - 2013 IEEE 52nd Annual Conference on Decision and Control, CDC 2013
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 52nd IEEE Conference on Decision and Control, CDC 2013
Y2 - 10 December 2013 through 13 December 2013
ER -
