Resolution-enhancement of photoacoustic microscopy by modulation quenching of nanoparticles

Gregor Langer, Patricia M.A. Farias, Andreas Stingl, Raquel Milani, Bianca Buchegger, Jaroslaw Jacak, Andre Galembeck, Thomas A. Klar, Thomas Berer

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review


In this work, we theoretically and experimentally deal with photoacoustic resolution enhancement by means of saturated modulation quenching. It is shown that experimental systems for resolution enhancement with saturated modulation quenching in fluorescence microscopy are not necessarily suited for photoacoustic modulation quenching. Here, we show that modulation quenching is not limited to fluorescent dyes but can be also applied to metallic nanoparticles. For modulation quenching in photoacoustic microscopy it is sufficient that the signal saturates with increasing excitation intensity.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510623989
Publication statusPublished - 2019
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
Duration: 3 Feb 20196 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco


  • Intensity modulation
  • Non-linear photoacoustic microscopy
  • Photoacoustic microscopy
  • Saturated modulation quenching


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