Rapid and efficacious adsorption of crocetin monogentiobiosyl ester following oral administration in rats

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Abstract

Crocetin (1) and its glycosylesters are water-soluble carotenoids representing the main components of the yellow pigments of saffron and gardenia. Crocetin (2) is well absorbed, whereas crocetin digentiobiosyl ester (crocin (2)) is not absorbed in the intestine as such. The present study was aimed at determining the absorption profile of crocetin monogentiobiosyl ester (crocetin-MGE (3)) in rats. Rats were orally administered crocetin-MGE (3) over 7 days and sequentially crocetin (1) at the same dose after a wash-out period of 10 days. Rats were treated over seven days. The levels of crocetin-MGE (3) and crocetin (1) in plasma were evaluated following administration of crocetin-MGE (3) or crocetin (1). Crocetin-MGE (3) was obtained by controlled hydrolysis of crocin. The results demonstrated that crocetin-MGE (3) was rapidly absorbed with a mean time to reach maximum concentration (Tmax) of 0.5 h comparable to that obtained for crocetin (1). It is also partially metabolized to crocetin (1). Crocetin-MGE (3) is rapidly and efficiently absorbed as such and is metabolized to crocetin (1).

Original languageEnglish
Title of host publicationOccurrences, Structure, Biosynthesis, and Health Benefits Based on their Evidences of Medicinal Phytochemicals in Vegetables and Fruits
PublisherNova Science Publishers, Inc.
Pages109-128
Number of pages20
ISBN (Electronic)9781536155648
Publication statusPublished - 1 Jan 2019

Keywords

  • Crocetin
  • Crocetin monogentiobiosyl ester
  • Crocin hydrolysis
  • Gardenia jasminoides extracts
  • Pharmacokinetics
  • Plasma absorption
  • Sprague-dawley rats

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