Integrated, round-the-clock patient care is becoming one of the key topics for IT applications in eHealth. This paper discusses how to achieve technical as well as semantic interoperability for integrated healthcare. Integrating the Healthcare Enterprise (IHE) plays an important role. The worldwide initiative IHE aims to optimize the interoperability of IT Systems in medicine and healthcare, using international standards. Documents, based on the Health Level Seven Clinical Document Architecture (HL7 CDA) standard, which can be electronically exchanged between healthcare systems, represent an integral part in a comprehensive solution. Since uniform semantic standards are only used rudimentarily in these documents it is seldom possible to directly compare, check (on plausibility, correctness and completeness) or integrate document content. Such integration is only possible in consideration of semantics and domain specific differences. An example for efficient data exchange using an IHE-compliant system is presented.