PRIMOS: An integrated platform for exploring protein-protein interactions

Thomas Kern, Michael Kommenda, Viktoria Dorfer, Johann Bauer, Kamil Önder

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review


The knowledge of protein-protein interactions (PPIs) is of prominent importance for modelling cellular processes, understanding of diseases and functional interpretation of post-genomic data. However, it is an elaborate task to obtain knowledge for specific proteins because it is spread over several databases. The Protein Interaction and Molecule Search (PRIMOS) platform integrates PPI data from several major PPI databases and thus eases knowledge acquisition considerably. Data integration is accomplished by mapping every interacting protein to its corresponding protein in UniProt, which makes the different PPI datasets comparable and allows detecting both congruent and conflicting information. Every imported PPI is reassessed by a homology-based validation scheme, which helps scientists to distinguish between trustworthy PPIs and false-positive PPIs that are frequently contained in today's PPI databases. The integrated dataset can be explored through a sophisticated Web interface and can be visualized within the PRIMOS Interaction Viewer. PRIMOS is publicly available online at

Original languageEnglish
Title of host publicationProceedings of 21st European Modeling and Simulation Symposium EMSS 2009
PublisherDIPTEM University of Genova
Number of pages6
Publication statusPublished - 2009
Event21st European Modeling and Simulation Symposium, EMSS 2009 - Puerto de la Cruz, Spain
Duration: 23 Sept 200925 Sept 2009


Conference21st European Modeling and Simulation Symposium, EMSS 2009
CityPuerto de la Cruz


  • Bio database
  • Bioinformatics
  • Data integration
  • Data reassessment
  • PPI search
  • PPI validation
  • PPI viewing
  • Protein-protein interaction


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