Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers

Henry Reyer, Jürgen Zentek, Klaus Männer, Ibrahim M.I. Youssef, Tobias Aumiller, Julian Weghuber, Klaus Wimmers, Andreas S. Mueller

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Phytogenic feed additives represent a potential alternative to antibiotics with attributed health and growth-promoting effects. Chickens supplemented with an essential oil blend, a Quillaja saponin blend, or a combination of both phytogenic preparations showed a comprehensively and significantly improved apparent ileal digestibility of crude protein and amino acids compared to control birds. Accordingly, holistic transcriptomic analyses of jejunum and liver samples indicated alterations of macromolecule transporters and processing pathways likely culminating in an increased uptake and metabolizing of carbohydrates and fatty acids. Complementary analyses in Caco-2 showed a significant increase in transporter recruitment to the membrane (SGLT1 and PEPT1) after addition of essential oils and saponins. Although the penetrance of effects differed for the used phytogenic feed additives, the results indicate for an overlapping mode of action including local effects at the intestinal border and systemic alterations of macronutrient metabolism resulting in an improved performance of broilers.

Original languageEnglish
Pages (from-to)6821-6830
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number32
DOIs
Publication statusPublished - 16 Aug 2017

Keywords

  • digestibility
  • essential oil
  • gene expression
  • PEPT1
  • saponin
  • SGLT1
  • Caco-2 Cells
  • Ileum/metabolism
  • Thymus Plant/chemistry
  • Humans
  • Digestion
  • Illicium/chemistry
  • Proteins/genetics
  • Animal Feed/analysis
  • Animals
  • Saponins/analysis
  • Origanum/chemistry
  • Oils, Volatile/analysis
  • Chickens/genetics
  • Food Additives/metabolism
  • Rosmarinus/chemistry

Fingerprint Dive into the research topics of 'Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers'. Together they form a unique fingerprint.

Cite this