Neuropil fiber reduction in brain tumors observed by atomic force microscopy

Kurt Schilcher, Rene Silye, Hans-Peter Huber

Research output: Contribution to journalReview article

2 Citations (Scopus)


Atomic force microscopy plays a fundamental role in the investigation of biological processes at nanometer level. In this study we used atomic force microscopy on routine uncovered histological brain samples to gain a detailed insight into the complex brain's architecture at a high magnification and a high resolution. We have applied this method to post mortem and neurosurgical brain specimens and the images revealed morphological details concerning the organisation of the network-like neuropil and the reduction in its fibres in neoplastically transformed astrocytic brain tumors. The data suggest the use of the neuropil fiber reduction as a diagnostic marker to assess the degree of astrocytomas. The results clearly demonstrate that atomic force microscopy could serve as a powerful tool in clinical diagnostics.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalJournal of Advanced Microscopy Research
Issue number2
Publication statusPublished - Aug 2010


  • Astrocytoma
  • Atomic Force Microscopy
  • Clinical Diagnostics
  • Neuropathology
  • Neuropil


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