Monitoring of disease activity by measurement of inflammatory markers in atopic dermatitis in childhood

G. Halmerbauer, T. Frischer, D. Y. Koller

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Serum levels of soluble interleukin-2 receptor (sIL-2R), intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule (ELAM- 1), and eosinophil cationic protein (ECP) were measured in 20 patients with atopic dermatitis before and after 4 days' treatment with prednisolone p.o. as well as in 16 healthy, nonatopic controls. Before steroid treatment, patients with atopic dermatitis demonstrated significantly higher serum levels of sIL-2R, ICAM-1, and ECP than healthy controls (P<0.001), whereas ELAM-1 levels were not different between the groups. After 4 days of steroid treatment, clinical improvement was associated with a decrease of sIL-2R (P<0.003), ICAM-1 (P<0.004), and ECP serum levels (P<0.003), but ELAM-1 levels remained unchanged. Both serum ECP and sIL-2R levels were significantly correlated with disease severity before as well as after steroid treatment. Changes of sIL-2R concentrations were strongly related to the changes of ECP levels. In addition, changes of serum sIL-2R and ECP levels in percentage were correlated with clinical improvement. These results indicate that the determination of sIL-2R and ECP serum levels may be useful in monitoring disease activity in atopic dermatitis in childhood, especially in treatment trials.

Original languageEnglish
Pages (from-to)765-769
Number of pages5
Issue number7
Publication statusPublished - 1997


  • Atopic dermatitis
  • ELAM-1
  • Eosinophil cationic protein
  • ICAM-1
  • sIL-2R
  • Eosinophil Granule Proteins
  • Severity of Illness Index
  • Prednisolone/administration & dosage
  • Humans
  • Male
  • E-Selectin/analysis
  • Ribonucleases
  • Dermatitis, Atopic/drug therapy
  • Blood Proteins/analysis
  • Drug Monitoring/methods
  • Intercellular Adhesion Molecule-1/analysis
  • Adolescent
  • Anti-Inflammatory Agents/administration & dosage
  • Biomarkers
  • Female
  • Receptors, Interleukin-2/analysis
  • Child


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