In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods

Roberto Casanas; Hermann Scharfetter; A Altes; A Remacha; P Sarda; J Sierra; Robert Merwa; Karl Hollaus; Javier Rosell

doi:10.1109/IEMBS.2003.1280788

Abstract

We study the feasibility of a new non-invasive method to measure hepatic iron overload using a magnetic induction (MI) based system. Experimental data (in vitro and in-vivo) were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. We estimate the response of the system using analytical expressions for the in-vitro study and the finite element method (FEM) for the in-vivo study. Seventeen in-vitro liver samples have been measured. Measurements were compared with a biochemical iron estimation procedure. A significant agreement is observed (R=0.94, P<0.001) between biochemical and MI results. The systems and procedures were adapted for in-vivo measurements. Ten patients and 8 volunteers were measured. We show the results for these two groups and two different estimators.

Original language	English
Pages	3064-3067
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2003.1280788
Publication status	Published - 2003
Event	XXV Annual International Conference of the IEEE Engineering in Medicine and Biology - Cancun, Mexico Duration: 17 Sept 2003 → 21 Sept 2003

Conference

Conference	XXV Annual International Conference of the IEEE Engineering in Medicine and Biology
Country/Territory	Mexico
City	Cancun
Period	17.09.2003 → 21.09.2003

Keywords

Heinodiroinatosis
Hepatic iron
Magnetic induction

Access to Document

10.1109/IEMBS.2003.1280788

Cite this

Casanas, R., Scharfetter, H., Altes, A., Remacha, A., Sarda, P., Sierra, J., Merwa, R., Hollaus, K., & Rosell, J. (2003). In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods. 3064-3067. Abstract from XXV Annual International Conference of the IEEE Engineering in Medicine and Biology, Cancun, Mexico. https://doi.org/10.1109/IEMBS.2003.1280788

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title = "In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods",

abstract = "We study the feasibility of a new non-invasive method to measure hepatic iron overload using a magnetic induction (MI) based system. Experimental data (in vitro and in-vivo) were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. We estimate the response of the system using analytical expressions for the in-vitro study and the finite element method (FEM) for the in-vivo study. Seventeen in-vitro liver samples have been measured. Measurements were compared with a biochemical iron estimation procedure. A significant agreement is observed (R=0.94, P<0.001) between biochemical and MI results. The systems and procedures were adapted for in-vivo measurements. Ten patients and 8 volunteers were measured. We show the results for these two groups and two different estimators.",

keywords = "Heinodiroinatosis, Hepatic iron, Magnetic induction",

author = "Roberto Casanas and Hermann Scharfetter and A Altes and A Remacha and P Sarda and J Sierra and Robert Merwa and Karl Hollaus and Javier Rosell",

year = "2003",

doi = "10.1109/IEMBS.2003.1280788",

language = "English",

pages = "3064--3067",

note = "XXV Annual International Conference of the IEEE Engineering in Medicine and Biology ; Conference date: 17-09-2003 Through 21-09-2003",

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Casanas, R, Scharfetter, H, Altes, A, Remacha, A, Sarda, P, Sierra, J, Merwa, R, Hollaus, K & Rosell, J 2003, 'In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods', XXV Annual International Conference of the IEEE Engineering in Medicine and Biology, Cancun, Mexico, 17.09.2003 - 21.09.2003 pp. 3064-3067. https://doi.org/10.1109/IEMBS.2003.1280788

In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods. / Casanas, Roberto; Scharfetter, Hermann; Altes, A et al.
2003. 3064-3067 Abstract from XXV Annual International Conference of the IEEE Engineering in Medicine and Biology, Cancun, Mexico.

Research output: Contribution to conference › Abstract › peer-review

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T1 - In-Vitro and In-Vivo Measurement of Iron Concentration in Human Hepatic Tissue by Magnetic Induction Methods

AU - Casanas, Roberto

AU - Scharfetter, Hermann

AU - Altes, A

AU - Remacha, A

AU - Sarda, P

AU - Sierra, J

AU - Merwa, Robert

AU - Hollaus, Karl

AU - Rosell, Javier

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N2 - We study the feasibility of a new non-invasive method to measure hepatic iron overload using a magnetic induction (MI) based system. Experimental data (in vitro and in-vivo) were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. We estimate the response of the system using analytical expressions for the in-vitro study and the finite element method (FEM) for the in-vivo study. Seventeen in-vitro liver samples have been measured. Measurements were compared with a biochemical iron estimation procedure. A significant agreement is observed (R=0.94, P<0.001) between biochemical and MI results. The systems and procedures were adapted for in-vivo measurements. Ten patients and 8 volunteers were measured. We show the results for these two groups and two different estimators.

AB - We study the feasibility of a new non-invasive method to measure hepatic iron overload using a magnetic induction (MI) based system. Experimental data (in vitro and in-vivo) were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. We estimate the response of the system using analytical expressions for the in-vitro study and the finite element method (FEM) for the in-vivo study. Seventeen in-vitro liver samples have been measured. Measurements were compared with a biochemical iron estimation procedure. A significant agreement is observed (R=0.94, P<0.001) between biochemical and MI results. The systems and procedures were adapted for in-vivo measurements. Ten patients and 8 volunteers were measured. We show the results for these two groups and two different estimators.

KW - Heinodiroinatosis

KW - Hepatic iron

KW - Magnetic induction

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