Improvements of lung function in cystic fibrosis

Erich Tauber, Gerhard Halmerbauer, Christian Gartner, Regina Rath, Thomas Frischer, Claudia Wojnarowski, Irmgard Eichler

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Improved care for patients with cystic fibrosis (CF) has led to their improved survival. We analyzed retrospectively whether improvements in lung function (LF) could be detected in our CF patients over the decade 1980-1990. In 72 patients, 153 LF measurements were performed in their first year of life (1980-1991), and then 189 LF measurements were performed again in 60 of those patients during their sixth year of life (1987-1997). Regression analysis was performed on LF parameters at age 6 years. When adjusting for weight, height, gender, and LF in the first year of life, the date of subsequent measurement was positively associated with FEV1 (P < 0.01) and MEF50% (P < 0.05) and negatively with FRCpleth (P < 0.05). The proposed model predicts a child's FEV1 at age 6 to be 75% of predicted if born in 1980, but 108% of predicted when born in 1990. Improved CF care is the most likely explanation for this observation.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalPediatric Pulmonology
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2002

Keywords

  • Childhood
  • Cystic fibrosis
  • Infant
  • Lung function
  • Natural history

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