Identification of diurnal patterns in insulin action from measured CGM data for patients with T1DM

Florian Reiterer, Harald Kirchsteiger, Guido Freckmann, Luigi Del Re

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review

10 Citations (Scopus)


We propose a method to identify diurnal changes in insulin action in patients suffering from type 1 diabetes mellitus (T1DM) based on data recorded by continuous glucose monitoring systems (CGMS). In order to do so the data is fitted using a continuous time transfer function including time dependent terms. The identified values for the insulin needs per gram of carbohydrate were compared with the patient-specific carbohydrate-to-insulin-ratios used for the calculation of the bolus insulin needs. A good agreement between the identified parameters and values determined by diabetologists were found. Furthermore, the diurnal variations in insulin action (as inferred from the changes in the patient-specific carbohydrate-to-insulin-ratios) could be reproduced. The identified models, including the diurnal changes in insulin action and the information on the intra-patient variability, have the potential to be used in future studies for managing the blood glucose level of patients, e.g. in a smart bolus calculator.

Original languageEnglish
Title of host publication2015 European Control Conference, ECC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages6
ISBN (Electronic)9783952426937
Publication statusPublished - 16 Nov 2015
Externally publishedYes
EventEuropean Control Conference, ECC 2015 - Linz, Austria
Duration: 15 Jul 201517 Jul 2015

Publication series

Name2015 European Control Conference, ECC 2015


ConferenceEuropean Control Conference, ECC 2015


  • Biomedical Systems
  • Blood Glucose Control
  • System Identification
  • Type 1 Diabetes


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