@inproceedings{ac03506e711d4562bb23bad851b45028,
title = "Identification of diurnal patterns in insulin action from measured CGM data for patients with T1DM",
abstract = "We propose a method to identify diurnal changes in insulin action in patients suffering from type 1 diabetes mellitus (T1DM) based on data recorded by continuous glucose monitoring systems (CGMS). In order to do so the data is fitted using a continuous time transfer function including time dependent terms. The identified values for the insulin needs per gram of carbohydrate were compared with the patient-specific carbohydrate-to-insulin-ratios used for the calculation of the bolus insulin needs. A good agreement between the identified parameters and values determined by diabetologists were found. Furthermore, the diurnal variations in insulin action (as inferred from the changes in the patient-specific carbohydrate-to-insulin-ratios) could be reproduced. The identified models, including the diurnal changes in insulin action and the information on the intra-patient variability, have the potential to be used in future studies for managing the blood glucose level of patients, e.g. in a smart bolus calculator.",
keywords = "Biomedical Systems, Blood Glucose Control, System Identification, Type 1 Diabetes",
author = "Florian Reiterer and Harald Kirchsteiger and Guido Freckmann and {Del Re}, Luigi",
year = "2015",
month = nov,
day = "16",
doi = "10.1109/ECC.2015.7330516",
language = "English",
series = "2015 European Control Conference, ECC 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1--6",
booktitle = "2015 European Control Conference, ECC 2015",
address = "United States",
note = "European Control Conference, ECC 2015 ; Conference date: 15-07-2015 Through 17-07-2015",
}