Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility.

Renate Haselgrübler, Peter Lanzerstorfer, Clemens Röhrl, Flora Stübl, Jonas Schurr, Bettina Schwarzinger, Clemens Schwarzinger, Mario Brameshuber, Stefan Wieser, Stephan Winkler, Julian Weghuber

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An increase in adipose tissue is caused by the increased size and number of adipocytes. Lipids accumulate in intracellular stores, known as lipid droplets (LDs). Recent studies suggest that parameters such as LD size, shape and dynamics are closely related to the development of obesity. Berberine (BBR), a natural plant alkaloid, has been demonstrated to possess anti-obesity effects. However, it remains unknown which cellular processes are affected by this compound or how effective herbal extracts containing BBR and other alkaloids actually are. For this study, we used extracts of Coptis chinensis, Mahonia aquifolium, Berberis vulgaris and Chelidonium majus containing BBR and other alkaloids and studied various processes related to adipocyte functionality. The presence of extracts resulted in reduced adipocyte differentiation, as well as neutral lipid content and rate of lipolysis. We observed that the intracellular fatty acid exchange was reduced in different LD size fractions upon treatment with BBR and Coptis chinensis. In addition, LD motility was decreased upon incubation with BBR, Coptis chinensis and Chelidonium majus extracts. Furthermore, Chelidonium majus was identified as a potent fatty acid uptake inhibitor. This is the first study that demonstrates the selected regulatory effects of herbal extracts on adipocyte function.

Original languageEnglish
Article number10492
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • Adipocytes/chemistry
  • Berberine/pharmacology
  • Berberis/chemistry
  • Cell Differentiation/drug effects
  • Cell Line
  • Chelidonium/chemistry
  • Chromatography, Gas
  • Chromatography, High Pressure Liquid
  • Coptis/chemistry
  • Fatty Acids/metabolism
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hypolipidemic Agents/pharmacology
  • Lipid Droplets/drug effects
  • Lipids/analysis
  • Lipolysis/drug effects
  • Mahonia/chemistry
  • Plant Extracts/pharmacology

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