High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Taras Sych, Jan Schlegel, Hanna M.G. Barriga, Miina Ojansivu, Leo Hanke, Florian Weber, R. Beklem Bostancioglu, Kariem Ezzat, Herbert Stangl, Birgit Plochberger, Jurga Laurencikiene, Samir El Andaloussi, Daniel Fürth, Molly M. Stevens, Erdinc Sezgin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.

Original languageEnglish
Pages (from-to)587-590
Number of pages4
JournalNature Biotechnology
Volume42
Issue number4
Early online dateJun 2023
DOIs
Publication statusPublished - Apr 2024

Keywords

  • Particle Size
  • Liposomes/chemistry
  • Nanoparticles/chemistry

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