Glucose prognosis by grammatical evolution

J. Ignacio Hidalgo, J. Manuel Colmenar, G. Kronberger, S. M. Winkler

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review


Patients suffering from Diabetes Mellitus illness need to control their levels of sugar by a restricted diet, a healthy life and in the cases of those patients that do not produce insulin (or with a severe defect on the action of the insulin they produce), by injecting synthetic insulin before and after the meals. The amount of insulin, namely bolus, to be injected is usually estimated based on the experience of the doctor and of the own patient. During the last years, several computational tools have been designed to suggest the boluses for each patient. Some of the successful approaches to solve this problem are based on obtaining a model of the glucose levels which is then applied to estimate the most appropriate dose of insulin. In this paper we describe some advances in the application of evolutionary computation to obtain those models. In particular, we extend some previous works with Grammatical Evolution, a branch of Genetic Programming. We present results for ten real patients on the prediction on several time horizons. We obtain reliable and individualized predictive models of the glucose regulatory system, eliminating restrictions such as linearity or limitation on the input parameters.

Original languageEnglish
Title of host publicationComputer Aided Systems Theory – EUROCAST 2017 - 16th International Conference, Revised Selected Papers
EditorsRoberto Moreno-Diaz, Alexis Quesada-Arencibia, Franz Pichler
Number of pages9
ISBN (Print)9783319747170
Publication statusPublished - 2018
Event16th International Conference on Computer Aided Systems Theory, EUROCAST 2017 - Las Palmas de Gran Canaria, Spain
Duration: 19 Feb 201724 Feb 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10671 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference16th International Conference on Computer Aided Systems Theory, EUROCAST 2017
CityLas Palmas de Gran Canaria


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