Abstract
This paper reports the results of experiments designed to determine the effect of linotroban (CAS 141443-73-4) a selective thromboxane (TXA2) receptor antagonist with novel antithrombotic activity, on renal function in conscious male and female rats. Linotroban was administered subcutaneously at doses of 0, 6, 24, 48 and 96 mg/kg/24 h by osmotic minipumps over 6 days. Inulin (Inutest®) and para-aminohippuric acid (PAH) clearances were determined on the last day of linotroban treatment. These agents were delivered by a slow release tablet planted s.c. five days after the start of the linotroban treatment. Linotroban did not significantly alter renal functions, although there was a significant difference in GFR (glomerular filtration rate) for male and female rats receiving the highest dose. Linotroban is well tolerated but the difference in renal function between male and female rats at the highest dose may reflect a threshold of renal tolerance.
| Original language | English |
|---|---|
| Pages (from-to) | 1026-1030 |
| Number of pages | 5 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 47 |
| Issue number | 9 |
| Publication status | Published - Sept 1997 |
Keywords
- CAS 141443-74-4
- Inulin, clearance
- Linotroban, effect on kidney function
- Thromboxane receptor antagonist
- para-Aminohippuric acid, clearance