Diagnosis of neurodegenerative diseases based on multi-modal hemodynamic classification of the brain

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review

Abstract

Accurate diagnostic assessment of metabolic processes in nuclear medicine diagnostic imaging, e.g. SPECT and PET, rely on specific localization of physiological activity. The major step in precise staging of neuro-degenerative diseases is robust, patient-specific classification of the brain. In this work a vascularization-based classification strategy for MRI datasets of the brain is introduced to handle variability of patient's anatomy. The vascularization-based classification utilizes skeletonization in combination with m-adjacency to construct a hierarchical vessel tree from binary pre-segmentations. Based on the vessel topology, the brain voxels are classified with respect to a minimal distance criterion from the vessel branches they are assigned to. This blood-supply oriented approach shows proper segmentation of respective anatomical regions of the human brain. Results are validated on T1-weighted brainweb database.

Original languageEnglish
Title of host publicationComputer Aided Systems Theory, EUROCAST 2011 - 13th International Conference, Revised Selected Papers
Pages209-216
Number of pages8
EditionPART 2
DOIs
Publication statusPublished - 2012
Event13th International Conference on Computer Aided Systems Theory, Eurocast 2011 - Las Palmas de Gran Canaria, Spain
Duration: 6 Feb 201111 Feb 2011
http://www.iuctc.ulpgc.es/spain/eurocast2011/

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume6928 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference13th International Conference on Computer Aided Systems Theory, Eurocast 2011
CountrySpain
CityLas Palmas de Gran Canaria
Period06.02.201111.02.2011
Internet address

Keywords

  • morphological classification
  • skeletonization
  • vessel tree modeling

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