Cholesterol transfer at the plasma membrane

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Cholesterol homeostasis is of central importance for life. Therefore, cells have developed a divergent set of pathways to meet their cholesterol needs. In this review, we focus on the direct transfer of cholesterol from lipoprotein particles to the cell membrane. More molecular details on the transfer of lipoprotein-derived lipids were gained by recent studies using phospholipid bilayers. While amphiphilic lipids are transferred right after contact of the lipoprotein particle with the membrane, the transfer of core lipids is restricted. Amphiphilic lipid transfer gains special importance in genetic diseases impairing lipoprotein metabolism like familial hypercholesterolemia. Taken together, these data indicate that there is a constant exchange of amphiphilic lipids between lipoprotein particles and the cell membrane.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalAtherosclerosis
Volume290
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Bilayer
  • Cholesterol
  • Lipoproteins
  • Plasma membrane
  • Transfer
  • Cholesterol, LDL/metabolism
  • ATP Binding Cassette Transporter, Subfamily G, Member 1/metabolism
  • Humans
  • Cholesterol, HDL/metabolism
  • Scavenger Receptors, Class B/metabolism
  • Apolipoprotein B-100/metabolism
  • Receptors, LDL/metabolism
  • Endocytosis
  • Biological Transport
  • Cholesterol/blood
  • Cell Membrane/metabolism
  • ATP Binding Cassette Transporter 1/metabolism

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