Bio-inspired microneedle design for efficient drug/vaccine coating

Cristina Plamadeala; Saransh R. Gosain; Florian Hischen; Boris Buchroithner; Sujitha Puthukodan; Jaroslaw Jacak; Andrea Bocchino; Derek Whelan; Conor O’Mahony; Werner Baumgartner; Johannes Heitz

doi:10.1007/s10544-019-0456-z

Bio-inspired microneedle design for efficient drug/vaccine coating

Cristina Plamadeala, Saransh R. Gosain, Florian Hischen, Boris Buchroithner, Sujitha Puthukodan, Jaroslaw Jacak, Andrea Bocchino, Derek Whelan, Conor O’Mahony, Werner Baumgartner, Johannes Heitz

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles’ surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process.

Original language	English
Article number	8
Pages (from-to)	8
Journal	Biomedical Microdevices
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/s10544-019-0456-z
Publication status	Published - 16 Dec 2019

Keywords

Biomimetics
Directed fluid transport
Microfluidics
Microneedles
Two-photon polymerization
Pharmaceutical Preparations/chemistry
Biomimetics/instrumentation
Needles
Vaccines/chemistry
Equipment Design

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10544-019-0456-z

Cite this

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abstract = "Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles{\textquoteright} surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process.",

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AU - Gosain, Saransh R.

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AU - Puthukodan, Sujitha

AU - Jacak, Jaroslaw

AU - Bocchino, Andrea

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AU - O’Mahony, Conor

AU - Baumgartner, Werner

AU - Heitz, Johannes

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AB - Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles’ surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process.

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Bio-inspired microneedle design for efficient drug/vaccine coating

Abstract

Keywords

UN SDGs

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