Atomic force microscopy

M. Duman, I. Neundlinger, R. Zhu, J. Preiner, C. Lamprecht, L. A. Chtcheglova, C. Rankl, T. Puntheeranurak, A. Ebner, P. Hinterdorfer

Research output: Chapter in Book/Report/Conference proceedingsChapterpeer-review

1 Citation (Scopus)


Atomic force microscopy (AFM) allows high-resolution topographical images to be obtained at the nanometer scale together with single molecule force measurements on biological samples in their physiological environment. Therefore, it is a powerful tool for detecting the forces and the dynamics of the interaction between individual ligands and receptors on cellular surfaces. This article describes sample preparation methods, different AFM imaging modes, AFM tip functionalization, current methodology, and applications of molecular recognition studies using AFM.

Original languageEnglish
Title of host publicationComprehensive Biophysics
Number of pages33
ISBN (Print)9780080957180
Publication statusPublished - 2012


  • Atomic force microscopy
  • Cell fixation
  • Cell immobilization
  • Cellular membrane
  • Contact mode imaging
  • Dynamic mode imaging
  • Fluorescence microscopy
  • Force mapping
  • Intermittent (tapping) mode imaging
  • Magnetic AC mode imaging
  • Membrane channels
  • Membrane receptors
  • Molecular recognition force spectroscopy
  • Simultaneous topography and recognition imaging


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