Applying a decision support system in clinical practice: results from melanoma diagnosis.

Stephan Dreiseitl, Michael Binder, Staal Vinterbo, Harald Kittler

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The work reported in this paper investigates the use of a decision-support tool for the diagnosis of pigmented skin lesions in a real-world clinical trial with 511 patients and 3827 lesion evaluations. We analyzed a number of outcomes of the trial, such as direct comparison of system performance in laboratory and clinical setting, the performance of physicians using the system compared to a control dermatologist without the system, and repeatability of system recommendations. The results show that system performance was significantly less in the real-world setting compared to the laboratory setting (c-index of 0.87 vs. 0.94, p = 0.01). Dermatologists using the system achieved a combined sensitivity of 85% and combined specificity of 95%. We also show that the process of acquiring lesion images using digital dermoscopy devices needs to be standardized before sufficiently high repeatability of measurements can be assured.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
Publication statusPublished - 2007


  • Decision Support Systems, Clinical
  • Dermoscopy/methods
  • Diagnosis, Computer-Assisted
  • Humans
  • Melanoma/diagnosis
  • Sensitivity and Specificity
  • Skin Neoplasms/diagnosis


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