TY - JOUR
T1 - Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition
AU - Sandner, Georg Philipp
AU - König, Alice
AU - Wallner, Melanie
AU - Weghuber, Julian
N1 - Funding Information:
This work was created within a research project of the Austrian Competence Centre for Feed and Food Quality, Safety and Innovation (FFoQSI). The COMET-K1 Competence Centre FFoQSI is funded by the Austrian ministries BMVIT, BMDW and the Austrian provinces Niederoesterreich, Upper Austria and Vienna within the scope of COMET - Competence Centers for Excellent Technologies. The programme COMET is handled by the Austrian Research Promotion Agency FFG. This work was also funded by the Christian Doppler Forschungsgesellschaft (Josef Ressel Center for Phytogenic Drug Research).
Publisher Copyright:
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/8
Y1 - 2021/3/8
N2 - In the field of (food) toxicology, there is a strong trend of replacing animal trials with alternative methods for the assessment of adverse health effects in humans. The replacement of animal trials is not only driven by ethical concerns but also by the number of potential testing substances (food additives, packaging material, contaminants, and toxicants), which is steadily increasing. In vitro 2D cell culture applications in combination with in silico modeling might provide an applicable first response. However, those systems lack accurate predictions of metabolic actions. Thus, alternative in vivo models could fill the gap between cell culture and animal trials. In this review, we highlight relevant studies in the field and spotlight the applicability of alternative models, including C. elegans, D. rerio, Drosophila, HET-CAM and Lab-on-a-chip.
AB - In the field of (food) toxicology, there is a strong trend of replacing animal trials with alternative methods for the assessment of adverse health effects in humans. The replacement of animal trials is not only driven by ethical concerns but also by the number of potential testing substances (food additives, packaging material, contaminants, and toxicants), which is steadily increasing. In vitro 2D cell culture applications in combination with in silico modeling might provide an applicable first response. However, those systems lack accurate predictions of metabolic actions. Thus, alternative in vivo models could fill the gap between cell culture and animal trials. In this review, we highlight relevant studies in the field and spotlight the applicability of alternative models, including C. elegans, D. rerio, Drosophila, HET-CAM and Lab-on-a-chip.
KW - food toxicology
KW - alternative models
KW - C. elegans
KW - Drosophila
KW - D. rerio
KW - HET-CAM
KW - Lab-on-a-chip
UR - http://www.scopus.com/inward/record.url?scp=85102208358&partnerID=8YFLogxK
U2 - 10.1080/10408398.2021.1895060
DO - 10.1080/10408398.2021.1895060
M3 - Review article
SN - 1040-8398
VL - 62
SP - 5965
EP - 5982
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
IS - 22
ER -