A versatile micropatterning approach for studying live cell signalling events

Peter Lanzerstorfer, Ulrike Müller, Roland Hager, Cindy Dirscherl, Klavdiya Gordiyenko, Christof M. Niemeyer, Sebastian Springer, Julian Weghuber

Research output: Chapter in Book/Report/Conference proceedingsConference contributionpeer-review

Abstract

Protein-protein interactions (PPIs) are an important part of biological processes, above all in cellular signal transduction. Here, we present a versatile live cell assay based on antibody micropatterns that allows the visualization, measurement, and quantitation of such interactions in the natural environment of the cell. Methodological variations and the potential of the micropatterning assay are demonstrated on the basis of different biological examples.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1528-1529
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period27.10.201931.10.2019

Keywords

  • Micropatterning
  • Protein-protein interaction
  • TIRFM

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