Project Details

Description

Surface analytical methods such as high-speed atomic force microscopy (HS-AFM), quartz crystal microbalance (QCM) or surface plasmon resonance (SPR) are important tools in biophysical research. However, their application to native cell membranes is not straightforward because they are limited to the study of very flat and mechanically stable surfaces to achieve optimal sensitivity. In the present project, we will therefore develop a method to extract native cell membranes from living cells and subsequently apply them to appropriately flat, mechanically stable substrates such as mica, glass or SiO2. In this way, we will realize so-called native surface-supported cell membranes (NOZ), which are compatible with the experimental techniques mentioned above. These methodological developments will serve as a basis for the submission of follow-up projects in which the course of various molecular processes, such as the activation of different immune reactions or the interaction of viruses and bacteria with these native cell membranes, will be investigated and characterized in detail.

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Short titleBF-NOZ
StatusActive
Effective start/end date01.09.202131.08.2022

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