Projects per year
Personal profile
About me
After my graduation in Technical Physics from the JKU, I joined Prof. Peter Hinterdorfer and proceeded with my PhD studies on different atomic force microscopy (AFM) related topics. I contributed to the development and application of novel AFM-based imaging and single molecule force-spectroscopic (SMFS) methods that were applied to different biological systems, including membrane proteins, viral particles, and cells. In addition, I pioneered higher harmonic AFM imaging of biological membranes in liquids and expanded the methodical background of the AFM based simultaneous topography and recognition imaging (TREC) technique. I used my Macke-Scholarship for a research stay abroad at the Ando Group in Japan where I gained profound knowledge about operating the high speed-AFM. This resulted in a widely recognized publication about the dynamics of antibodies bound to bacterial S-layer and viral membranes (recommended by F1000Prime and highlighted in BioTechniques). I continued my work on HSAFM applications with a focus on the dynamics of aquaporines (together with Dr. Horner) and the bacterial translocation machinery (FWF grant P25844-B22 in collaboration with Prof. Pohl, JKU) from which four publications emerged. In another collaboration together with Birgit Plochberger from the University of Applied Sciences Upper Austria and Prof. H. Stangl from the Medical University of Vienna we discovered a yet unknown, receptor-independent mechanism of cargo transfer between lipoprotein particles (HDL, LDL) and biomembranes. Following my initial HS-AFM work on antibody dynamics, I started a (still ongoing) collaboration with GENMAB, a Dutch biotech company, on the principle mechanism of antibody-mediated complement activation on antigenic surfaces. As a result of this work, I started another collaboration with Prof. Suzan Rooijakkers (UMC Utrecht, Netherlands) on complement activation on bacterial surfaces, from which two joint publications emerged. Taken together, my current research focusses on the molecular dynamics and interactions that occur at the membrane interface, including the dynamics of membrane proteins and their binding partners, and the molecular mechanisms that lead to antibody mediated immune activation with particular interest on the classical complement pathway and Fc-receptor mediated antibody dependent cell cytotoxicity.
Education/Academic qualification
PhD Biophysics, PhD, Johannes Kepler University Linz
Award Date: 18 Jan 2008
Technical Physics, Dipl.-Ing., Johannes Kepler University Linz
Award Date: 18 Mar 2005
External positions
University lecturer, Johannes Kepler University Linz
2014 → …
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pH_HpUreI - pH-dependent structural dynamics/gating of HpUreI
01.06.2022 → 31.05.2025
Project: Research Project
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TCA3, TC-BIOsens
Lanzerstorfer, P., Kern, T., Preiner, J., Dornmayr-Pfaffenhuemer, M., Schurr, J., Haghofer, A. & Hauser, F.
01.01.2022 → 31.12.2025
Project: Research Project
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BF-NOZ - BF-Native supported cell membranes
Preiner, J., Marefat, M. & Saxinger, M.
01.09.2021 → 31.08.2022
Project: Research Project
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IgGMedCompAct - Determinants of IgG-mediated complement activation
Preiner, J., Frischauf, N., Strasser, J. & Saxinger, M.
01.01.2021 → 31.12.2024
Project: Research Project
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FcRClu - Elucidation of IgG oligomer mediated Fc receptor clustering
Preiner, J., Karner, A., Frischauf, N., Saxinger, M. & Marefat, M.
01.11.2020 → 31.10.2024
Project: Research Project
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Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers: Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers
Dirscherl, C., Löchte, S., Hein, Z., Kopicki, J-D., Harders, A. R., Linden, N., Karner, A., Preiner, J., Weghuber, J., Garcia-Alai, M., Uetrecht, C., Zacharias, M., Piehler, J., Lanzerstorfer, P. & Springer, S., 2022, In: Journal of Cell Science.Research output: Contribution to journal › Article › peer-review
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C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases
Zwarthoff, S. A., Widmer, K., Kuipers, A., Strasser, J., Ruyken, M., Aerts, P. C., Haas, C. J. C. D., Ugurlar, D., Vidarsson, G., Strijp, J. A. G. V., Gros, P., Parren, P. W. H. I., Kessel, K. P. M. V., Preiner, J., Beurskens, F. J., Schuurman, J., Ricklin, D. & Rooijakkers, S. H. M., 29 Jun 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2102787118.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Comprehensive label-free characterization of extracellular vesicles and their surface proteins
Priglinger, E., Strasser, J., Buchroithner, B., Weber, F., Wolbank, S., Auer, D., Grasmann, E., Arzt, C., Sivun, D., Grillari, J., Jacak, J., Preiner, J. & Gimona, M., 2021, (Accepted/In press) In: Journal of Extracellular Vesicles.Research output: Contribution to journal › Article › peer-review
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DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens
Hellmeier, J., Platzer, R., Eklund, A. S., Schlichthaerle, T., Karner, A., Motsch, V., Schneider, M. C., Kurz, E., Bamieh, V., Brameshuber, M., Preiner, J., Jungmann, R., Stockinger, H., Schütz, G. J., Huppa, J. B. & Sevcsik, E., 26 Jan 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 4, e2016857118.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Label-free characterization of an extracellular vesicle-based therapeutic
Priglinger, E., Strasser, J., Buchroithner, B., Weber, F., Wolbank, S., Auer, D., Grasmann, E., Arzt, C., Sivun, D., Grillari, J., Jacak, J., Preiner, J. & Gimona, M., Oct 2021, In: Journal of Extracellular Vesicles. 10, 12, e12156.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus)