As an evidence based business process analysis method, process mining can be used to investigate variations in clinical practice and delivery of care. However, to enable cross-organizational comparative analysis, healthcare institutions need a common ground for the description and representation of health data. In this work, we analyze different approaches, to describe clinical and patient pathways. The Healthcare Reference Model represents a bottom-up approach, the HL7 v3 RIM as a generic health information model represents a top-down approach and HL7 FHIR, the newest standard of the HL7 family stands in-between. We highlight similarities and differences according to interoperability and process mining tasks. We conclude that a standards (RIM) based top-down approach, and the derived FHIR approach respectively, is able to provide similar insights and, on top of that, operational support for the ETL process on all interoperability levels.