PRIMOS: An integrated platform for exploring protein-protein interactions

Thomas Kern, Michael Kommenda, Viktoria Dorfer, Johann Bauer, Kamil Önder

Publikation: Beitrag in Buch/Bericht/TagungsbandKonferenzbeitragBegutachtung

Abstract

The knowledge of protein-protein interactions (PPIs) is of prominent importance for modelling cellular processes, understanding of diseases and functional interpretation of post-genomic data. However, it is an elaborate task to obtain knowledge for specific proteins because it is spread over several databases. The Protein Interaction and Molecule Search (PRIMOS) platform integrates PPI data from several major PPI databases and thus eases knowledge acquisition considerably. Data integration is accomplished by mapping every interacting protein to its corresponding protein in UniProt, which makes the different PPI datasets comparable and allows detecting both congruent and conflicting information. Every imported PPI is reassessed by a homology-based validation scheme, which helps scientists to distinguish between trustworthy PPIs and false-positive PPIs that are frequently contained in today's PPI databases. The integrated dataset can be explored through a sophisticated Web interface and can be visualized within the PRIMOS Interaction Viewer. PRIMOS is publicly available online at http://primos.fh-hagenberg.at.

OriginalspracheEnglisch
TitelProceedings of 21st European Modeling and Simulation Symposium EMSS 2009
Herausgeber (Verlag)DIPTEM University of Genova
Seitenumfang6
PublikationsstatusVeröffentlicht - 2009
Veranstaltung21st European Modeling and Simulation Symposium, EMSS 2009 - Puerto de la Cruz, Spanien
Dauer: 23 Sep. 200925 Sep. 2009

Konferenz

Konferenz21st European Modeling and Simulation Symposium, EMSS 2009
Land/GebietSpanien
OrtPuerto de la Cruz
Zeitraum23.09.200925.09.2009

Fingerprint

Untersuchen Sie die Forschungsthemen von „PRIMOS: An integrated platform for exploring protein-protein interactions“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren