TY - JOUR
T1 - Predictors of lung function in infants at high risk of atopy
T2 - Effect of allergen avoidance
AU - Tauber, Erich
AU - Gartner, Christian
AU - Halmerbauer, Gerhard
AU - Rath, Regina
AU - Schelberger, Barbara
AU - Schierl, Michael
AU - Frischer, Thomas
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/4
Y1 - 2002/4
N2 - Children of atopic parents are recognised as being at higher risk of developing bronchial asthma, drawing the attention of prevention strategies towards this population. Due to recent advances, lung function abnormalities in asthmatic children may now be measured early in life. The aim of this investigation was to examine possible predictors of lung function development in a sub sample of high-risk infants who took part in an allergy avoidance study. In 60 babies of atopic parents, measurements of upper airways inflammation were performed at 4 weeks of age, respiratory symptoms were assessed at 6 and 12 months of age, and lung function (Vmax, FRC) was measured at 18 months by the rapid thoracoabdominal compression technique. Twenty-eight babies were enrolled in an allergen avoidance program, and 32 recruited as controls. No significant differences were detected for V'maxFRC between the intervention group (mean 331 ml s-1) and the control group (359 ml s-1), P=0.382. A multiple linear regression model could explain levels of V'max, FRC by weight gain since birth (beta = -35.35 ml s-1 kg-1, P=0.022) and by eosinophilic cationic protein (ECP) (beta= -0.95 ml s-1 μl-1, P=0.044), but not by intervention. Lung function measured at the age of 18 months in high-risk children is associated with weight gain and nasal ECP.
AB - Children of atopic parents are recognised as being at higher risk of developing bronchial asthma, drawing the attention of prevention strategies towards this population. Due to recent advances, lung function abnormalities in asthmatic children may now be measured early in life. The aim of this investigation was to examine possible predictors of lung function development in a sub sample of high-risk infants who took part in an allergy avoidance study. In 60 babies of atopic parents, measurements of upper airways inflammation were performed at 4 weeks of age, respiratory symptoms were assessed at 6 and 12 months of age, and lung function (Vmax, FRC) was measured at 18 months by the rapid thoracoabdominal compression technique. Twenty-eight babies were enrolled in an allergen avoidance program, and 32 recruited as controls. No significant differences were detected for V'maxFRC between the intervention group (mean 331 ml s-1) and the control group (359 ml s-1), P=0.382. A multiple linear regression model could explain levels of V'max, FRC by weight gain since birth (beta = -35.35 ml s-1 kg-1, P=0.022) and by eosinophilic cationic protein (ECP) (beta= -0.95 ml s-1 μl-1, P=0.044), but not by intervention. Lung function measured at the age of 18 months in high-risk children is associated with weight gain and nasal ECP.
KW - Airway inflammation
KW - Asthma
KW - ECP
KW - Lung function
KW - Prevention
KW - Weight
KW - Allergens
KW - Age Factors
KW - Humans
KW - Infant
KW - Risk
KW - Functional Residual Capacity
KW - Chi-Square Distribution
KW - Case-Control Studies
KW - Regression Analysis
KW - Antimicrobial Cationic Peptides/analysis
KW - Nasal Lavage Fluid/immunology
KW - Lung/physiopathology
KW - Hypersensitivity/immunology
KW - Weight Gain
KW - Infant, Newborn
UR - http://www.scopus.com/inward/record.url?scp=0036553644&partnerID=8YFLogxK
U2 - 10.1053/rmed.2001.1254
DO - 10.1053/rmed.2001.1254
M3 - Article
C2 - 12000001
SN - 0954-6111
VL - 96
SP - 230
EP - 235
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 4
ER -