TY - GEN
T1 - Hybrid control of type 1 diabetes bolus therapy
AU - Trogmann, H.
AU - Kirchsteiger, H.
AU - Del Re, L.
PY - 2010
Y1 - 2010
N2 - The probably best treatment of type 1 diabetes mellitus (T1DM) would be an artificial pancreas (AP). Unfortunately, AP is still not available as AP requires continuous glucose measurements and continuous insulin delivery systems which are not available. The vast majority of patients do not use any of them but instead resort to a few irregularly sampled measurements and single insulin administrations ('insulin bolus'). Choosing time and quantity of a bolus delivery is critical for the health of T1DM patients, and ideally this should be done on basis of a model. While good physiological models for populations exist, in general they can hardly be tuned to specific patients and are therefore not very useful for bolus choice. Against this background, this paper proposes to see the issue of model based bolus choice in a hybrid framework in which the continuous time meal and insulin model is replaced by a discrete parameterization which associates to each meal and bolus a function of given, patient specific shape whose amplitude depends on the respective amounts. This allows restating the standard model predictive control of the AP design by a line search method.
AB - The probably best treatment of type 1 diabetes mellitus (T1DM) would be an artificial pancreas (AP). Unfortunately, AP is still not available as AP requires continuous glucose measurements and continuous insulin delivery systems which are not available. The vast majority of patients do not use any of them but instead resort to a few irregularly sampled measurements and single insulin administrations ('insulin bolus'). Choosing time and quantity of a bolus delivery is critical for the health of T1DM patients, and ideally this should be done on basis of a model. While good physiological models for populations exist, in general they can hardly be tuned to specific patients and are therefore not very useful for bolus choice. Against this background, this paper proposes to see the issue of model based bolus choice in a hybrid framework in which the continuous time meal and insulin model is replaced by a discrete parameterization which associates to each meal and bolus a function of given, patient specific shape whose amplitude depends on the respective amounts. This allows restating the standard model predictive control of the AP design by a line search method.
UR - http://www.scopus.com/inward/record.url?scp=79953140479&partnerID=8YFLogxK
U2 - 10.1109/CDC.2010.5717404
DO - 10.1109/CDC.2010.5717404
M3 - Conference contribution
AN - SCOPUS:79953140479
SN - 9781424477456
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 4721
EP - 4726
BT - 2010 49th IEEE Conference on Decision and Control, CDC 2010
T2 - 2010 49th IEEE Conference on Decision and Control, CDC 2010
Y2 - 15 December 2010 through 17 December 2010
ER -