TY - JOUR
T1 - Higher Harmonic Atomic Force Microscopy: Imaging of Biological Membranes in Liquid
AU - Preiner, Johannes
AU - Tang, Jilin
AU - Pastushenko, Vasili Ph.
AU - Hinterdorfer, Peter
PY - 2007/7/25
Y1 - 2007/7/25
N2 - The contribution of higher harmonics to the movement of a dynamic force microscope cantilever
interacting with a sample in liquid was investigated. The amplitude of the second harmonic has been
found to be an order of magnitude higher in liquid than in air, reflecting an increased sensitivity to local
variations in elasticity and interaction geometries. A theoretical model of the tip-sample interactions in
liquid was introduced and shown to be consistent with experimental findings. Second harmonic amplitude
images were recorded on soft biological samples yielding a lateral resolution of °0:5 nm.
AB - The contribution of higher harmonics to the movement of a dynamic force microscope cantilever
interacting with a sample in liquid was investigated. The amplitude of the second harmonic has been
found to be an order of magnitude higher in liquid than in air, reflecting an increased sensitivity to local
variations in elasticity and interaction geometries. A theoretical model of the tip-sample interactions in
liquid was introduced and shown to be consistent with experimental findings. Second harmonic amplitude
images were recorded on soft biological samples yielding a lateral resolution of °0:5 nm.
UR - http://www.scopus.com/inward/record.url?scp=34547467104&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.99.046102
DO - 10.1103/PhysRevLett.99.046102
M3 - Article
SN - 0031-9007
VL - 99
JO - Physical Review Letters
JF - Physical Review Letters
IS - 4
M1 - 046102
ER -