Combined acid hydrolysis and fermentation improves bioactivity of citrus flavonoids in vitro and in vivo

Alice König, Nadiia Sadova, Marion Dornmayr, Bettina Schwarzinger, Cathrina Neuhauser, Verena Stadlbauer, Melanie Wallner, Jakob Woischitzschläger, Andreas Müller, Rolf Tona, Daniel Kofel, Julian Weghuber

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

3 Zitate (Scopus)

Abstract

Many bioactive plant compounds, known as phytochemicals, have the potential to improve health. Unfortunately, the bioavailability and bioactivity of phytochemicals such as polyphenolic flavonoids are reduced due to conjugation with sugar moieties. Here, we combine acid hydrolysis and tailored fermentation by lactic acid bacteria (Lactiplantibacillus plantarum) to convert the biologically less active flavonoid glycosides hesperidin and naringin into the more active aglycones hesperetin and naringenin. Using a comprehensive approach, we identify the most effective hydrolysis and fermentation conditions to increase the concentration of the aglycones in citrus extracts. The higher cellular transport and bioactivity of the biotransformed citrus extract are also demonstrated in vitro and in vivo. Superior antioxidant, anti-inflammatory and cell migration activities in vitro, as well as intestinal barrier protecting and antioxidant activities in Drosophila melanogaster are identified. In conclusion, the presented biotransformation approach improves the bioactivity of flavonoids, clearly traced back to the increase in aglycone content.
OriginalspracheEnglisch
Aufsatznummer1083
Seiten (von - bis)1083
FachzeitschriftCommunications Biology
Jahrgang6
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - 25 Okt. 2023

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  • 64th Drosophila Research Conference

    Sadova, N. (Teilnehmer)

    1 März 20235 März 2023

    Aktivität: Teilnahme an oder Organisation einer VeranstaltungTeilnahme an einer Konferenz, einem Workshop

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