Co-localization of CD3 and prion protein in Jurkat lymphocytes after hypothermal stimulation

Susanne Wurm, Christian Paar, Alois Sonnleitner, Max Sonnleitner, Otmar Höglinger, Christoph Romanin, Christian Wechselberger

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

11 Zitate (Scopus)

Abstract

While long-term effects of temperature treatment in respect of, e.g., gene-expression and cellular function have already been studied in some detail, nothing is known on the physiological responses of lymphocytes during short-term hypothermal shifts. In this report, we characterized the effects of such a stimulation using the human lymphocyte cell line Jurkat E6.1 and present evidence that warming from 4 to 37 degrees C for only 2 min is sufficient to cause co-localization of CD3, prion protein and the lipid-raft ganglioside GM1 paralleling lymphocyte activation as observed by Ca(2+) mobilization and mitogen-activated protein kinase-phosphorylation.

OriginalspracheEnglisch
Seiten (von - bis)121-125
Seitenumfang5
FachzeitschriftFEBS Letters
Jahrgang566
Ausgabenummer1-3
DOIs
PublikationsstatusVeröffentlicht - 21 Mai 2004
Extern publiziertJa

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