Classification of the states of human adaptive immune systems by analyzing immunoglobulin and t cell receptors using immunexplorer

Susanne Schaller, Johannes Weinberger, Raúl Jiménez-Heredia, Martin Danzer, Stephan M. Winkler

Publikation: Beitrag in Buch/Bericht/TagungsbandKonferenzbeitragBegutachtung

Abstract

The behavior and actions of the human adaptive immune system and its key players, namely B and T cells, are often hard to understand in their entirety. We here present a workflow for modelling the states of adaptive immune systems by analyzing B and T cell receptor repertoires using next-generation sequencing data. For our workflow, we have blood and kidney tissues from diseased patients, who suffered from different kidney diseases (e.g., renal carcinoma), and healthy proband. A set of features based on clonal expansion and diversity of immunoglobulins and T cell receptor next-generation sequencing data, isolated from patients, are calculated. Using different machine learning methods such as support vector machines, random forests, artificial neural networks and genetic programming in HeuristicLab, we are able to classify and distinguish between healthy and diseased individuals up to 80% accuracy using ImmunExplorer.

OriginalspracheEnglisch
TitelComputer Aided Systems Theory – EUROCAST 2015 - 15th International Conference, Revised Selected Papers
Redakteure/-innenFranz Pichler, Roberto Moreno-Díaz, Alexis Quesada-Arencibia
Herausgeber (Verlag)Springer Verlag
Seiten302-309
Seitenumfang8
ISBN (Print)9783319273396
DOIs
PublikationsstatusVeröffentlicht - 2015
Veranstaltung15th International Conference on Computer Aided Systems Theory, Eurocast 2015 - Las Palmas, Gran Canaria, Spanien
Dauer: 8 Feb 201513 Feb 2015
http://eurocast2015.fulp.ulpgc.es/

Publikationsreihe

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Band9520
ISSN (Print)0302-9743
ISSN (elektronisch)1611-3349

Konferenz

Konferenz15th International Conference on Computer Aided Systems Theory, Eurocast 2015
LandSpanien
OrtLas Palmas, Gran Canaria
Zeitraum08.02.201513.02.2015
Internetadresse

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