Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Benedikt Nimmervoll, Lilia Chtcheglova, Kata Juhasz, N Cremades, F.A. Aprile, Alois Sonnleitner, Peter Hinterdorfer, L. Vigh, Johannes Preiner, Zolt Balogi

Publikation: Beitrag in FachzeitschriftArtikel

31 Zitate (Scopus)

Abstract

The stress inducible heat shock protein 70 (Hsp70) is present specifically on the tumour cell surface yet without a pro-tumour function revealed. We show here that cell surface localised Hsp70 (sHsp70) supports clathrin-independent endocytosis (CIE) in melanoma models. Remarkably, ability of Hsp70 to cluster on lipid rafts in vitro correlated with larger nano-domain sizes of sHsp70 in high sHsp70 expressing cell membranes. Interfering with Hsp70 oligomerisation impaired sHsp70-mediated facilitation of endocytosis. Altogether our findings suggest that a sub-fraction of sHsp70 co-localising with lipid rafts enhances CIE through oligomerisation and clustering. Targeting or utilising this tumour specific mechanism may represent an additional benefit for anti-cancer therapy.
OriginalspracheEnglisch
Seiten (von - bis)2747-2753
Seitenumfang7
FachzeitschriftFEBS Letters
Jahrgang589
Ausgabenummer19
DOIs
PublikationsstatusVeröffentlicht - 14 Sep. 2015

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