Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

Biochemistry, Genetics and Molecular Biology

• Rigidity 100%
• Cholesterol Synthesis 100%
• Cancer Cell 100%
• Drive 100%
• Cholesterol 100%
• Cell Membrane 66%
• Statin 66%
• Mevalonate Pathway 66%
• Colon 66%
• Molecular Mechanism 66%
• Metabolite 33%
• Cytotoxicity 33%
• Drug Resistance 33%
• Anticancer 33%
• Atomic Force Microscopy 33%
• Secondary Metabolite 33%
• Entomopathogenic Fungus 33%
• Oxysterol 33%
• Lanosterol 33%

Keyphrases

• Destruxin 100%
• Membrane Rigidity 100%
• Cancer Cell Resistance 100%
• Cholesterol Biosynthesis 100%
• Cholesterol 33%
• Resistant Cells 22%
• Mevalonate Pathway 22%
• Statins 22%
• Atomic Force Microscopy 11%
• Plasma Membrane 11%
• Cell Membrane 11%
• Secondary Metabolites 11%
• Mode of Action 11%
• Molecular Techniques 11%
• Entomopathogenic Fungi 11%
• Lanosterol 11%
• Colon Cancer Cells 11%
• Major Player 11%
• Oxysterols 11%
• HyPer 11%
• Membrane Reorganization 11%
• Synthesis Rate 11%
• HCT116 11%
• Highly Stable 11%
• Regulatory Mechanism 11%
• Resistance Phenotypes 11%
• Destruxin A 11%
• Zoledronic Acid 11%
• Cytotoxic Activity 11%
• Bioinsecticide 11%
• Adhesiveness 11%
• ABC Efflux Transporters 11%
• Anticancer Effect 11%
• Human Colon Cancer Cells 11%
• Resistance Development 11%
• Chemoresistance 11%
• Elevated Levels 11%
• Molecular Resistance Mechanisms 11%
• Biological Techniques 11%
• De Novo Cholesterol Synthesis 11%

Immunology and Microbiology

• Cell Membrane 100%
• Cancer Cell 100%
• Colon 100%
• Cholesterol Synthesis 100%
• Rigidity 100%
• Metabolite 50%
• Secondary Metabolite 50%
• Cytotoxicity 50%
• Carcinoma Cell 50%
• Entomopathogenic Fungi 50%
• Drug Resistance 50%