A Unique Photoreaction of Hypericinate Bound to Human Serum Albumin, Lipids, or Vesicles

Bettina Schwarzinger, Heinz Falk

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

4 Zitate (Scopus)

Abstract

Hypericinate bound to human serum albumin is effectively photo-bleached. This reaction occurs to a lesser extent for hypericinate incorporated into dipalmitoyl-phosphatidyl-cholin vesicles or lecithin. Surprisingly, the photo-bleaching was strongly retarded for the complex of hypericinate with bovine serum albumin. In homogeneous solutions in a variety of solvents, micellar systems, and in ethanolic solutions containing additives mimicking possibly active parts of the mentioned hosts, almost no photoreaction was discernible. No products besides hypericin could be recovered from a bleached system. It was concluded that the main photoreaction involves photo-reduction or photo-addition in which the product becomes specifically stabilized by the host, but reverts partly to hypericinate upon destruction of the complex.

OriginalspracheEnglisch
Seiten (von - bis)1353-1358
Seitenumfang6
FachzeitschriftMonatshefte fur Chemie
Jahrgang134
Ausgabenummer10
DOIs
PublikationsstatusVeröffentlicht - Okt. 2003
Extern publiziertJa

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