Personalization has been discussed in a number of domains such as learning, search or information retrieval. In the area of humancomputer interaction, personalization also plays a prominent role. For the variety of users, especially for those with impairments, interaction abilities vary drastically and for many it is not possible to use common interaction devices like a mouse or the touch screen of a smart phone (at least not with their predefined configuration). .is paper describes a personalized interaction approach based on i) modeling users' interaction abilities, ii) automated selection and configuration of interaction devices for the individual user, and iii) adaptive behavior of selected applications. It is not exclusively focused on the requirements of people with impairments but frequently takes up this target group as it might particularly benefit from interaction personalization concepts.