Projekte pro Jahr
Persönliches Profil
Über mich
After my graduation in Technical Physics from the JKU, I joined Prof. Peter Hinterdorfer and proceeded with my PhD studies on different atomic force microscopy (AFM) related topics. I contributed to the development and application of novel AFM-based imaging and single molecule force-spectroscopic (SMFS) methods that were applied to different biological systems, including membrane proteins, viral particles, and cells. In addition, I pioneered higher harmonic AFM imaging of biological membranes in liquids and expanded the methodical background of the AFM based simultaneous topography and recognition imaging (TREC) technique. I used my Macke-Scholarship for a research stay abroad at the Ando Group in Japan where I gained profound knowledge about operating the high speed-AFM. This resulted in a widely recognized publication about the dynamics of antibodies bound to bacterial S-layer and viral membranes (recommended by F1000Prime and highlighted in BioTechniques). I continued my work on HSAFM applications with a focus on the dynamics of aquaporines (together with Dr. Horner) and the bacterial translocation machinery (FWF grant P25844-B22 in collaboration with Prof. Pohl, JKU) from which four publications emerged. In another collaboration together with Birgit Plochberger from the University of Applied Sciences Upper Austria and Prof. H. Stangl from the Medical University of Vienna we discovered a yet unknown, receptor-independent mechanism of cargo transfer between lipoprotein particles (HDL, LDL) and biomembranes. Following my initial HS-AFM work on antibody dynamics, I started a (still ongoing) collaboration with GENMAB, a Dutch biotech company, on the principle mechanism of antibody-mediated complement activation on antigenic surfaces. As a result of this work, I started another collaboration with Prof. Suzan Rooijakkers (UMC Utrecht, Netherlands) on complement activation on bacterial surfaces, from which two joint publications emerged. Taken together, my current research focusses on the molecular dynamics and interactions that occur at the membrane interface, including the dynamics of membrane proteins and their binding partners, and the molecular mechanisms that lead to antibody mediated immune activation with particular interest on the classical complement pathway and Fc-receptor mediated antibody dependent cell cytotoxicity.
Bildung/Akademische Qualifikationen
Doktorrat Biophysik, Promovend, New developments in AFM imaging and single-molecule force microscopy, Johannes Kepler University Linz
Datum der Bewilligung: 18 Jän. 2008
Technische Physik, Dipl.-Ing., Selective IR emitters and detectors for gas-analysis, Johannes Kepler University Linz
Datum der Bewilligung: 18 März 2005
Externe Posten
Universitätslektor, Johannes Kepler University Linz
2014 → …
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pH_HpUreI - pH-abhängige strukturelle Dynamik/Gating von HpUreI
01.06.2022 → 31.05.2025
Projekt: Forschungsprojekt
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TCA3, TC-BIOsens
Lanzerstorfer, P., Kern, T., Preiner, J., Dornmayr-Pfaffenhuemer, M., Schurr, J., Haghofer, A. & Hauser, F.
01.01.2022 → 31.12.2025
Projekt: Forschungsprojekt
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IgGMedCompAct - Bestimmungsfaktoren IgG-vermittelter Komplementaktivierung
Preiner, J., Frischauf, N. & Strasser, J.
01.01.2021 → 31.12.2024
Projekt: Forschungsprojekt
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FcRClu - Aufklärung des IgG-Oligomer-vermittelten FcR-Clusterings
Preiner, J., Karner, A., Frischauf, N. & Marefat, M.
01.11.2020 → 31.10.2024
Projekt: Forschungsprojekt
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HS-AFM to study Fc:Fc interaction
Preiner, J., Karner, A., Frischauf, N. & Strasser, J.
01.09.2017 → 30.06.2024
Projekt: Forschungsprojekt
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A Mechanistic Model of Antigen- and IgG Subclass Dependent Antibody Oligomerization and Complement Binding
Preiner, J., Strasser, J., Frischauf, N. & Beurskens, F. J., März 2022.Publikation: Konferenzbeitrag › Poster
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Balanced cooperativity: How weak Fc-Fc interactions govern complement dependent cytotoxicity
Strasser, J., Frischauf, N., de Jong, R. N., Beurskens, F. J., Schuurman, J., Parren, P. W. H. I., Hinterdorfer, P. & Preiner, J., 16 März 2022.Publikation: Konferenzbeitrag › Poster
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Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers: Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers
Dirscherl, C., Löchte, S., Hein, Z., Kopicki, J-D., Harders, A. R., Linden, N., Karner, A., Preiner, J., Weghuber, J., Garcia-Alai, M., Uetrecht, C., Zacharias, M., Piehler, J., Lanzerstorfer, P. & Springer, S., 2022, in: Journal of Cell Science.Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung
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IgG oligomer mediated FcR clustering in the spotlight
Karner, A., Marefat, M., Hofmann, M., Siligan, C. & Preiner, J., 3 Nov. 2022.Publikation: Konferenzbeitrag › Poster
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Mechanisms and Implications of Antibody Oligomerization on Cell Surfaces
Strasser, J., Beurskens, F. J., Frischauf, N. & Preiner, J., 3 Nov. 2022.Publikation: Konferenzbeitrag › Poster
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How multivalent interactions trigger immune effector functions
Johannes Preiner (Redner*in) & Jürgen Strasser (Redner*in)
2 Nov. 2022 → 4 Nov. 2022Aktivität: Gespräch oder Vortrag › Geladener Gastvortrag
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A Mechanistic Model of Antigen- and IgG Subclass Dependent Antibody Oligomerization and Complement Binding
Johannes Preiner (Redner*in)
13 März 2022 → 18 März 2022Aktivität: Gespräch oder Vortrag › Geladener Gastvortrag
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How multivalent interactions trigger immune responses
Johannes Preiner (Redner*in)
10 Juli 2022Aktivität: Gespräch oder Vortrag › Vortrag
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How multivalent interactions trigger immune response
Johannes Preiner (Redner*in)
17 Juli 2022 → 21 Juli 2022Aktivität: Gespräch oder Vortrag › Geladener Gastvortrag
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Protein dynamics at the membrane interface
Johannes Preiner (Redner*in)
25 Mai 2022Aktivität: Gespräch oder Vortrag › Vortrag