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Persönliches Profil

Über mich

After my graduation in Technical Physics from the JKU, I joined Prof. Peter Hinterdorfer and proceeded with my PhD studies on different atomic force microscopy (AFM) related topics. I contributed to the development and application of novel AFM-based imaging and single molecule force-spectroscopic (SMFS) methods that were applied to different biological systems, including membrane proteins, viral particles, and cells. In addition, I pioneered higher harmonic AFM imaging of biological membranes in liquids and expanded the methodical background of the AFM based simultaneous topography and recognition imaging (TREC) technique. I used my Macke-Scholarship for a research stay abroad at the Ando Group in Japan where I gained profound knowledge about operating the high speed-AFM. This resulted in a widely recognized publication about the dynamics of antibodies bound to bacterial S-layer and viral membranes (recommended by F1000Prime and highlighted in BioTechniques). I continued my work on HSAFM applications with a focus on the dynamics of aquaporines (together with Dr. Horner) and the bacterial translocation machinery (FWF grant P25844-B22 in collaboration with Prof. Pohl, JKU) from which four publications emerged. In another collaboration together with Birgit Plochberger from the University of Applied Sciences Upper Austria and Prof. H. Stangl from the Medical University of Vienna we discovered a yet unknown, receptor-independent mechanism of cargo transfer between lipoprotein particles (HDL, LDL) and biomembranes. Following my initial HS-AFM work on antibody dynamics, I started a (still ongoing) collaboration with GENMAB, a Dutch biotech company, on the principle mechanism of antibody-mediated complement activation on antigenic surfaces. As a result of this work, I started another collaboration with Prof. Suzan Rooijakkers (UMC Utrecht, Netherlands) on complement activation on bacterial surfaces, from which two joint publications emerged. Taken together, my current research focusses on the molecular dynamics and interactions that occur at the membrane interface, including the dynamics of membrane proteins and their binding partners, and the molecular mechanisms that lead to antibody mediated immune activation with particular interest on the classical complement pathway and Fc-receptor mediated antibody dependent cell cytotoxicity.

Bildung/Akademische Qualifikationen

Biophysik, Habilitation, Protein Dynamics at the Membrane Interface, Johannes Kepler University Linz

Datum der Bewilligung: 24 Apr. 2023

Doktorrat Biophysik, Promovend, New developments in AFM imaging and single-molecule force microscopy, Johannes Kepler University Linz

Datum der Bewilligung: 18 Jän. 2008

Technische Physik, Dipl.-Ing., Selective IR emitters and detectors for gas-analysis, Johannes Kepler University Linz

Datum der Bewilligung: 18 März 2005

Externe Posten

Universitätslektor, Johannes Kepler University Linz

2014 → …


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