Aktivität: Gespräch oder Vortrag › Geladener Gastvortrag
Beschreibung
: Multivalent interactions enable complex molecular recognition and signaling processes, such as the initiation of the classical complement pathway (CCP). This presentation gives an overview on how the CCP is initiated through antigen-dependent oligomerization of IgGs and subsequent recognition and activation of the multivalent zymogen C1. The presented kinetic model may serve as a basis for optimizing antibody-engineering and PK/PD modelling.